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TAS1R2 has not been detected as a mutational cancer driver

TAS1R2
Ensembl id ENSG00000179002
Mutated samples
Coding Sequence 94 (1.4%)
Protein Affecting 63 (0.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TAS1R2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 38 24 6.50
Lung adenocarcinoma No 10 7 1.79
Renal clear cell carcinoma No 5 4 0.96
Colorectal adenocarcinoma No 6 4 1.75
Breast carcinoma No 5 3 0.26
Uterine corpus endometrioid carcinoma No 4 3 1.30
Lower grade glioma No 2 2 1.18
Stomach adenocarcinoma No 2 2 1.24
Small cell lung carcinoma No 2 2 2.90
Glioblastoma multiforme No 6 2 0.53
Esophageal carcinoma No 2 2 1.37
Prostate adenocarcinoma No 1 1 0.41
Hepatocarcinoma No 1 1 1.11
Pancreas adenocarcinoma No 1 1 0.47
Thyroid carcinoma No 1 1 0.31
Neuroblastoma No 1 1 0.48
Chronic lymphocytic leukemia No 1 1 0.34
Serous ovarian adenocarcinoma No 1 1 0.32
Head and neck squamous cell carcinoma No 2 1 0.27
Lung squamous cell carcinoma No 3 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence