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TARDBP has not been detected as a mutational cancer driver

TARDBP
Ensembl id ENSG00000120948
Mutated samples
Coding Sequence 34 (0.5%)
Protein Affecting 15 (0.2%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TARDBP gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Head and neck squamous cell carcinoma No 6 4 1.07
Uterine corpus endometrioid carcinoma No 4 3 1.30
Bladder carcinoma No 2 2 2.04
Serous ovarian adenocarcinoma No 3 2 0.63
Hepatocarcinoma No 2 1 1.11
Breast carcinoma No 1 1 0.09
Cutaneous melanoma No 6 1 0.27
Multiple myeloma No 1 1 1.45
Prostate adenocarcinoma No 2 0 0.00
Lung adenocarcinoma No 1 0 0.00
Medulloblastoma No 1 0 0.00
Lung squamous cell carcinoma No 2 0 0.00
Renal clear cell carcinoma No 1 0 0.00
Glioblastoma multiforme No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence