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TAF1 mutations in 9 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Bladder carcinoma, Breast carcinoma, Medulloblastoma, Neuroblastoma, Lower grade glioma, Stomach adenocarcinoma, Small cell lung carcinoma, Colorectal adenocarcinoma, Esophageal carcinoma

TAF1
Ensembl id ENSG00000147133
Mutated samples
Coding Sequence 157 (2.3%)
Protein Affecting 129 (1.9%)
Mode of action Activating
Known driver No
Cancer type Signals (Biases)
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TAF1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast carcinoma Yes 22 19 1.66
Small cell lung carcinoma Yes 8 6 8.70
Stomach adenocarcinoma Yes 5 5 3.11
Medulloblastoma Yes 3 3 1.43
Lower grade glioma Yes 4 3 1.78
Colorectal adenocarcinoma Yes 3 3 1.31
Bladder carcinoma Yes 3 2 2.04
Neuroblastoma Yes 2 2 0.95
Esophageal carcinoma Yes 2 2 1.37
Uterine corpus endometrioid carcinoma No 21 20 8.70
Cutaneous melanoma No 24 18 4.88
Lung squamous cell carcinoma No 12 12 6.90
Lung adenocarcinoma No 10 9 2.30
Head and neck squamous cell carcinoma No 10 7 1.87
Renal clear cell carcinoma No 8 5 1.20
Serous ovarian adenocarcinoma No 5 5 1.58
Glioblastoma multiforme No 7 4 1.06
Pancreas adenocarcinoma No 1 1 0.47
Thyroid carcinoma No 2 1 0.31
Chronic lymphocytic leukemia No 2 1 0.34
Diffuse B cell lymphoma No 1 1 4.35
Hepatocarcinoma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence