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TACC3 has not been detected as a mutational cancer driver

TACC3
Ensembl id ENSG00000013810
Mutated samples
Coding Sequence 61 (0.9%)
Protein Affecting 40 (0.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TACC3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 21 10 2.71
Bladder carcinoma No 6 6 6.12
Serous ovarian adenocarcinoma No 4 4 1.27
Head and neck squamous cell carcinoma No 5 4 1.07
Lung adenocarcinoma No 4 3 0.77
Breast carcinoma No 3 3 0.26
Stomach adenocarcinoma No 4 3 1.86
Uterine corpus endometrioid carcinoma No 2 2 0.87
Glioblastoma multiforme No 3 2 0.53
Small cell lung carcinoma No 2 1 1.45
Esophageal carcinoma No 1 1 0.68
Acute lymphocytic leukemia No 1 1 0.82
Hepatocarcinoma No 1 0 0.00
Lung squamous cell carcinoma No 1 0 0.00
Renal clear cell carcinoma No 2 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence