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SRGAP3 mutations in 6 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Lung squamous cell carcinoma, Renal clear cell carcinoma, Uterine corpus endometrioid carcinoma, Stomach adenocarcinoma, Colorectal adenocarcinoma, Esophageal carcinoma

SRGAP3
Ensembl id ENSG00000196220
Mutated samples
Coding Sequence 93 (1.4%)
Protein Affecting 65 (1.0%)
Mode of action Activating
Known driver Yes
Cancer type Signals (Biases)
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SRGAP3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung squamous cell carcinoma Yes 7 5 2.87
Stomach adenocarcinoma Yes 6 5 3.11
Colorectal adenocarcinoma Yes 3 3 1.31
Renal clear cell carcinoma Yes 2 2 0.48
Uterine corpus endometrioid carcinoma Yes 2 2 0.87
Esophageal carcinoma Yes 3 2 1.37
Cutaneous melanoma No 43 30 8.13
Lung adenocarcinoma No 8 8 2.05
Breast carcinoma No 3 2 0.17
Head and neck squamous cell carcinoma No 3 2 0.53
Bladder carcinoma No 2 1 1.02
Thyroid carcinoma No 1 1 0.31
Multiple myeloma No 1 1 1.45
Glioblastoma multiforme No 2 1 0.26
Hepatocarcinoma No 2 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 4 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence