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SPTA1 has not been detected as a mutational cancer driver

SPTA1
Ensembl id ENSG00000163554
Mutated samples
Coding Sequence 543 (8.0%)
Protein Affecting 392 (5.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SPTA1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 118 78 21.14
Lung adenocarcinoma No 73 63 16.11
Lung squamous cell carcinoma No 49 37 21.26
Breast carcinoma No 39 29 2.53
Glioblastoma multiforme No 29 27 7.12
Stomach adenocarcinoma No 40 26 16.15
Esophageal carcinoma No 44 26 17.81
Head and neck squamous cell carcinoma No 32 22 5.87
Uterine corpus endometrioid carcinoma No 16 14 6.09
Prostate adenocarcinoma No 20 11 4.53
Renal clear cell carcinoma No 10 10 2.40
Bladder carcinoma No 12 9 9.18
Small cell lung carcinoma No 15 9 13.04
Colorectal adenocarcinoma No 10 7 3.06
Neuroblastoma No 6 6 2.86
Non small cell lung carcinoma No 7 5 16.13
Hepatocarcinoma No 8 4 4.44
Thyroid carcinoma No 5 4 1.24
Serous ovarian adenocarcinoma No 5 4 1.27
Multiple myeloma No 1 1 1.45
Pancreas adenocarcinoma No 2 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Lower grade glioma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence