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SPHKAP has not been detected as a mutational cancer driver

SPHKAP
Ensembl id ENSG00000153820
Mutated samples
Coding Sequence 303 (4.5%)
Protein Affecting 238 (3.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SPHKAP gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 124 96 26.02
Lung squamous cell carcinoma No 26 25 14.37
Lung adenocarcinoma No 20 17 4.35
Breast carcinoma No 17 14 1.22
Small cell lung carcinoma No 13 13 18.84
Head and neck squamous cell carcinoma No 16 13 3.47
Bladder carcinoma No 8 7 7.14
Renal clear cell carcinoma No 8 7 1.68
Esophageal carcinoma No 10 7 4.79
Stomach adenocarcinoma No 10 6 3.73
Prostate adenocarcinoma No 6 5 2.06
Uterine corpus endometrioid carcinoma No 7 4 1.74
Serous ovarian adenocarcinoma No 6 4 1.27
Neuroblastoma No 4 3 1.43
Multiple myeloma No 3 3 4.35
Colorectal adenocarcinoma No 4 3 1.31
Glioblastoma multiforme No 4 3 0.79
Pancreas adenocarcinoma No 3 2 0.93
Chronic lymphocytic leukemia No 7 2 0.69
Hepatocarcinoma No 1 1 1.11
Acute myeloid leukemia No 1 1 0.51
Thyroid carcinoma No 1 1 0.31
Non small cell lung carcinoma No 1 1 3.23
Lower grade glioma No 2 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence