IntOGen - SPEN gene cancer mutations

SPEN is detected as a mutational cancer driver

SPEN reports

Methods
Mutation distribution

Gene details

SPEN
Ensembl ID ENSG00000065526 Transcript ID ENST00000375759 Protein ID ENSP00000364912
Cancer types where is driver 12 Cohorts where is driver 21 Mutated samples 127 Mutations 1,242
Mode of action Ambiguous
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence