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SPAG16 has not been detected as a mutational cancer driver

SPAG16
Ensembl id ENSG00000144451
Mutated samples
Coding Sequence 121 (1.8%)
Protein Affecting 57 (0.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SPAG16 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 41 21 5.69
Lung adenocarcinoma No 16 11 2.81
Lung squamous cell carcinoma No 9 7 4.02
Head and neck squamous cell carcinoma No 7 4 1.07
Stomach adenocarcinoma No 6 3 1.86
Esophageal carcinoma No 6 3 2.05
Breast carcinoma No 4 2 0.17
Uterine corpus endometrioid carcinoma No 3 2 0.87
Prostate adenocarcinoma No 2 1 0.41
Renal clear cell carcinoma No 1 1 0.24
Small cell lung carcinoma No 1 1 1.45
Glioblastoma multiforme No 1 1 0.26
Hepatocarcinoma No 2 0 0.00
Medulloblastoma No 1 0 0.00
Neuroblastoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 12 0 0.00
Serous ovarian adenocarcinoma No 1 0 0.00
Pylocytic astrocytoma No 4 0 0.00
Colorectal adenocarcinoma No 1 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence