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SP140 has not been detected as a mutational cancer driver

SP140
Ensembl id ENSG00000079263
Mutated samples
Coding Sequence 121 (1.8%)
Protein Affecting 83 (1.2%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SP140 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 56 41 11.11
Lung adenocarcinoma No 10 5 1.28
Breast carcinoma No 4 4 0.35
Lung squamous cell carcinoma No 4 4 2.30
Uterine corpus endometrioid carcinoma No 8 4 1.74
Multiple myeloma No 4 4 5.80
Stomach adenocarcinoma No 4 3 1.86
Hepatocarcinoma No 3 2 2.22
Bladder carcinoma No 3 2 2.04
Renal clear cell carcinoma No 2 2 0.48
Serous ovarian adenocarcinoma No 4 2 0.63
Small cell lung carcinoma No 2 2 2.90
Head and neck squamous cell carcinoma No 3 2 0.53
Prostate adenocarcinoma No 3 1 0.41
Thyroid carcinoma No 3 1 0.31
Lower grade glioma No 1 1 0.59
Diffuse B cell lymphoma No 1 1 4.35
Glioblastoma multiforme No 2 1 0.26
Esophageal carcinoma No 1 1 0.68
Non small cell lung carcinoma No 1 0 0.00
Colorectal adenocarcinoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence