SOS1 mutations in 1 Breast carcinoma project possibly contribute to the detection of the gene in the PAN-cancer anlaysis:

Breast carcinoma
Projects 6
1148 Samples
Coding sequence mutations (CSMs)
in driver genes 2330
in all genes 84945
Protein affecting mutations (PAMs)
in driver genes 2121
in all genes 45048
Ensembl id ENSG00000115904
Mutated samples
Coding Sequence 8 (0.7%)
Protein Affecting 7 (0.6%)
Mode of action Activating
Known driver No
Project Signals
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Breast carcinoma projects in all SOS1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast invasive carcinoma TCGA Yes 4 3 0.26
Breast cancer BROAD No 1 1 0.09
Breast Cancer Sanger Institute No 1 1 0.09
ER positive Breast cancer Washington University No 1 1 0.09
Triple Negative Breast Cancer UBC No 1 1 0.09
The mutations needle plot shows the distribution of the observed SOS1 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification