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SORCS2 has not been detected as a mutational cancer driver

SORCS2
Ensembl id ENSG00000184985
Mutated samples
Coding Sequence 102 (1.5%)
Protein Affecting 45 (0.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SORCS2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 39 16 4.34
Lung adenocarcinoma No 8 5 1.28
Uterine corpus endometrioid carcinoma No 10 5 2.17
Head and neck squamous cell carcinoma No 6 4 1.07
Breast carcinoma No 5 3 0.26
Glioblastoma multiforme No 3 3 0.79
Prostate adenocarcinoma No 2 2 0.82
Lung squamous cell carcinoma No 5 2 1.15
Serous ovarian adenocarcinoma No 2 2 0.63
Bladder carcinoma No 3 1 1.02
Renal clear cell carcinoma No 3 1 0.24
Colorectal adenocarcinoma No 2 1 0.44
Medulloblastoma No 1 0 0.00
Chronic lymphocytic leukemia No 10 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Stomach adenocarcinoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence