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SMG5 has not been detected as a mutational cancer driver

SMG5
Ensembl id ENSG00000198952
Mutated samples
Coding Sequence 98 (1.4%)
Protein Affecting 48 (0.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SMG5 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 20 12 3.25
Breast carcinoma No 13 10 0.87
Lung adenocarcinoma No 11 4 1.02
Head and neck squamous cell carcinoma No 7 4 1.07
Bladder carcinoma No 4 3 3.06
Uterine corpus endometrioid carcinoma No 7 3 1.30
Stomach adenocarcinoma No 8 3 1.86
Lung squamous cell carcinoma No 5 2 1.15
Colorectal adenocarcinoma No 4 2 0.87
Esophageal carcinoma No 3 2 1.37
Pancreas adenocarcinoma No 1 1 0.47
Small cell lung carcinoma No 2 1 1.45
Glioblastoma multiforme No 2 1 0.26
Hepatocarcinoma No 1 0 0.00
Renal clear cell carcinoma No 2 0 0.00
Thyroid carcinoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Multiple myeloma No 1 0 0.00
Lower grade glioma No 1 0 0.00
Serous ovarian adenocarcinoma No 3 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence