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SMC4 has not been detected as a mutational cancer driver

SMC4
Ensembl id ENSG00000113810
Mutated samples
Coding Sequence 76 (1.1%)
Protein Affecting 61 (0.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SMC4 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Head and neck squamous cell carcinoma No 9 9 2.40
Breast carcinoma No 10 8 0.70
Lung adenocarcinoma No 5 5 1.28
Bladder carcinoma No 5 5 5.10
Cutaneous melanoma No 11 5 1.36
Small cell lung carcinoma No 5 5 7.25
Colorectal adenocarcinoma No 5 5 2.18
Stomach adenocarcinoma No 5 4 2.48
Lung squamous cell carcinoma No 5 3 1.72
Uterine corpus endometrioid carcinoma No 5 3 1.30
Esophageal carcinoma No 3 3 2.05
Medulloblastoma No 2 2 0.95
Lower grade glioma No 2 2 1.18
Thyroid carcinoma No 1 1 0.31
Serous ovarian adenocarcinoma No 1 1 0.32
Pancreas adenocarcinoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence