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SMC1A is detected as a mutational cancer driver in 1 cancer type: Uterine corpus endometrioid carcinoma and in the PAN-cancer analysis

SMC1A
Ensembl id ENSG00000072501
Mutated samples
Coding Sequence 80 (1.2%)
Protein Affecting 66 (1.0%)
Mode of action Activating
Known driver No
Cancer type Signals (Biases)
UCEC F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SMC1A gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Uterine corpus endometrioid carcinoma Yes 10 10 4.35
Cutaneous melanoma Yes 10 8 2.17
Stomach adenocarcinoma Yes 4 4 2.48
Head and neck squamous cell carcinoma Yes 5 4 1.07
Lung adenocarcinoma Yes 5 3 0.77
Bladder carcinoma Yes 3 3 3.06
Colorectal adenocarcinoma Yes 3 3 1.31
Renal clear cell carcinoma Yes 3 2 0.48
Esophageal carcinoma Yes 2 2 1.37
Acute myeloid leukemia No 7 7 3.57
Breast carcinoma No 10 6 0.52
Glioblastoma multiforme No 5 5 1.32
Serous ovarian adenocarcinoma No 5 4 1.27
Medulloblastoma No 1 1 0.48
Lung squamous cell carcinoma No 2 1 0.57
Neuroblastoma No 1 1 0.48
Chronic lymphocytic leukemia No 2 1 0.34
Small cell lung carcinoma No 1 1 1.45
Hepatocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence