IntOGen - SMAD4 gene cancer mutations in PRAD

SMAD4 is detected as a mutational cancer driver in Prostate Adenocarcinoma

SMAD4 reports in Prostate Adenocarcinoma (PRAD)

Methods
Mutation distribution

Cancer type details

Prostate Adenocarcinoma
Cohorts 13 Samples 2,819 Mutations 9,128,298 Driver genes 104

Gene details

SMAD4
Ensembl ID ENSG00000141646 Transcript ID ENST00000342988 Protein ID ENSP00000341551
Cohorts where is driver 2 Mutated samples 12 Mutated samples (%) 0.43 Mutations 21
Mode of action Activating
Known driver True

Method signals per Cohort

Cohort	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Highlight in X-axis:

Mutation (GRCh38)	Protein Position	Samples	Samples (%)	Consequence