SMAD4 is detected as a mutational cancer driver in 3 Pancreas adenocarcinoma projects

Pancreas adenocarcinoma
Projects 3
214 Samples
Coding sequence mutations (CSMs)
in driver genes 416
in all genes 5701
Protein affecting mutations (PAMs)
in driver genes 409
in all genes 3002
Ensembl id ENSG00000141646
Mutated samples
Coding Sequence 42 (19.6%)
Protein Affecting 42 (19.6%)
Mode of action Loss of function
Known driver Yes
Project Signals
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Pancreas adenocarcinoma projects in all SMAD4 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Pancreatic cancer Johns Hopkins University Yes 31 31 14.49
Pancreatic cancer QCMG Yes 9 9 4.21
Pancreatic cancer OICR Yes 2 2 0.93
The mutations needle plot shows the distribution of the observed SMAD4 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification