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SMAD4 × Head and Neck Squamous Cell Carcinoma ×

SMAD4 is detected as a mutational cancer driver in Head and Neck Squamous Cell Carcinoma

SMAD4 reports in Head and Neck Squamous Cell Carcinoma (HNSC)

Cancer type details
Head and Neck Squamous Cell Carcinoma
Cohorts 6
Samples 818
Mutations 2,112,343
Driver genes 80
Gene details
SMAD4
Ensembl ID ENSG00000141646
Transcript ID ENST00000342988
Protein ID ENSP00000341551
Cohorts where is driver 2
Mutated samples 16
Mutated samples (%) 1.96
Mutations 21
Mode of action Loss of function
Known driver True
Method signals per Cohort
Cohort Methods Samples Samples (%)
ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination
Observed mutations in tumors
The mutations needle plot shows the distribution of the observed mutations along the protein sequence.
Mutation (GRCh38) Protein Position Samples Samples (%) Consequence