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SLC4A5 has not been detected as a mutational cancer driver

SLC4A5
Ensembl id ENSG00000188687
Mutated samples
Coding Sequence 89 (1.3%)
Protein Affecting 57 (0.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SLC4A5 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 31 13 3.52
Breast carcinoma No 13 11 0.96
Lung adenocarcinoma No 9 8 2.05
Bladder carcinoma No 4 4 4.08
Lung squamous cell carcinoma No 4 4 2.30
Serous ovarian adenocarcinoma No 4 4 1.27
Glioblastoma multiforme No 4 4 1.06
Hepatocarcinoma No 3 2 2.22
Pancreas adenocarcinoma No 1 1 0.47
Renal clear cell carcinoma No 1 1 0.24
Uterine corpus endometrioid carcinoma No 4 1 0.43
Stomach adenocarcinoma No 5 1 0.62
Colorectal adenocarcinoma No 1 1 0.44
Head and neck squamous cell carcinoma No 2 1 0.27
Esophageal carcinoma No 2 1 0.68
Non small cell lung carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence