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SLC4A4 has not been detected as a mutational cancer driver

SLC4A4
Ensembl id ENSG00000080493
Mutated samples
Coding Sequence 118 (1.7%)
Protein Affecting 82 (1.2%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SLC4A4 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 30 19 5.15
Head and neck squamous cell carcinoma No 18 13 3.47
Lung squamous cell carcinoma No 10 7 4.02
Lung adenocarcinoma No 6 6 1.53
Breast carcinoma No 7 6 0.52
Uterine corpus endometrioid carcinoma No 7 5 2.17
Bladder carcinoma No 4 4 4.08
Renal clear cell carcinoma No 4 3 0.72
Serous ovarian adenocarcinoma No 3 3 0.95
Glioblastoma multiforme No 4 3 0.79
Neuroblastoma No 3 2 0.95
Stomach adenocarcinoma No 2 2 1.24
Small cell lung carcinoma No 2 2 2.90
Colorectal adenocarcinoma No 4 2 0.87
Esophageal carcinoma No 4 2 1.37
Pancreas adenocarcinoma No 1 1 0.47
Chronic lymphocytic leukemia No 4 1 0.34
Multiple myeloma No 1 1 1.45
Non small cell lung carcinoma No 1 0 0.00
Lower grade glioma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence