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SLC11A1 has not been detected as a mutational cancer driver

SLC11A1
Ensembl id ENSG00000018280
Mutated samples
Coding Sequence 50 (0.7%)
Protein Affecting 22 (0.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SLC11A1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 19 6 1.63
Breast carcinoma No 3 3 0.26
Lung adenocarcinoma No 4 2 0.51
Colorectal adenocarcinoma No 3 2 0.87
Glioblastoma multiforme No 3 2 0.53
Lung squamous cell carcinoma No 1 1 0.57
Renal clear cell carcinoma No 1 1 0.24
Thyroid carcinoma No 1 1 0.31
Neuroblastoma No 1 1 0.48
Serous ovarian adenocarcinoma No 4 1 0.32
Stomach adenocarcinoma No 1 1 0.62
Head and neck squamous cell carcinoma No 1 1 0.27
Prostate adenocarcinoma No 1 0 0.00
Hepatocarcinoma No 1 0 0.00
Uterine corpus endometrioid carcinoma No 3 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Lower grade glioma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence