IntOGen - SIRPA gene cancer mutations

SIRPA is detected as a mutational cancer driver

SIRPA reports

Methods
Mutation distribution

Gene details

SIRPA
Ensembl ID ENSG00000198053 Transcript ID ENST00000622179 Protein ID ENSP00000478763
Cancer types where is driver 4 Cohorts where is driver 4 Mutated samples 18 Mutations 310
Mode of action Ambiguous
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence