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SIPA1L2 has not been detected as a mutational cancer driver

SIPA1L2
Ensembl id ENSG00000116991
Mutated samples
Coding Sequence 155 (2.3%)
Protein Affecting 115 (1.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SIPA1L2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 33 24 6.50
Lung adenocarcinoma No 22 18 4.60
Lung squamous cell carcinoma No 16 11 6.32
Stomach adenocarcinoma No 12 11 6.83
Uterine corpus endometrioid carcinoma No 12 8 3.48
Breast carcinoma No 11 7 0.61
Head and neck squamous cell carcinoma No 10 7 1.87
Renal clear cell carcinoma No 8 6 1.44
Glioblastoma multiforme No 7 6 1.58
Esophageal carcinoma No 5 5 3.42
Small cell lung carcinoma No 3 3 4.35
Bladder carcinoma No 4 2 2.04
Prostate adenocarcinoma No 1 1 0.41
Pancreas adenocarcinoma No 1 1 0.47
Thyroid carcinoma No 1 1 0.31
Chronic lymphocytic leukemia No 3 1 0.34
Lower grade glioma No 2 1 0.59
Serous ovarian adenocarcinoma No 2 1 0.32
Colorectal adenocarcinoma No 1 1 0.44
Neuroblastoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence