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SHROOM3 has not been detected as a mutational cancer driver

SHROOM3
Ensembl id ENSG00000138771
Mutated samples
Coding Sequence 126 (1.9%)
Protein Affecting 82 (1.2%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SHROOM3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 43 26 7.05
Lung adenocarcinoma No 11 8 2.05
Lung squamous cell carcinoma No 11 8 4.60
Head and neck squamous cell carcinoma No 10 7 1.87
Uterine corpus endometrioid carcinoma No 9 6 2.61
Breast carcinoma No 5 5 0.44
Prostate adenocarcinoma No 3 3 1.23
Bladder carcinoma No 4 3 3.06
Glioblastoma multiforme No 3 3 0.79
Renal clear cell carcinoma No 2 2 0.48
Thyroid carcinoma No 2 2 0.62
Lower grade glioma No 2 2 1.18
Stomach adenocarcinoma No 4 2 1.24
Esophageal carcinoma No 2 2 1.37
Non small cell lung carcinoma No 1 1 3.23
Serous ovarian adenocarcinoma No 1 1 0.32
Colorectal adenocarcinoma No 1 1 0.44
Hepatocarcinoma No 1 0 0.00
Medulloblastoma No 1 0 0.00
Chronic lymphocytic leukemia No 7 0 0.00
Pylocytic astrocytoma No 3 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence