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SF3B4 has not been detected as a mutational cancer driver

SF3B4
Ensembl id ENSG00000143368
Mutated samples
Coding Sequence 59 (0.9%)
Protein Affecting 25 (0.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SF3B4 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung adenocarcinoma No 8 6 1.53
Cutaneous melanoma No 12 6 1.63
Breast carcinoma No 5 2 0.17
Uterine corpus endometrioid carcinoma No 4 2 0.87
Serous ovarian adenocarcinoma No 2 2 0.63
Stomach adenocarcinoma No 8 2 1.24
Bladder carcinoma No 2 1 1.02
Lung squamous cell carcinoma No 4 1 0.57
Non small cell lung carcinoma No 1 1 3.23
Colorectal adenocarcinoma No 1 1 0.44
Glioblastoma multiforme No 3 1 0.26
Renal clear cell carcinoma No 3 0 0.00
Thyroid carcinoma No 1 0 0.00
Small cell lung carcinoma No 1 0 0.00
Head and neck squamous cell carcinoma No 1 0 0.00
Esophageal carcinoma No 3 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence