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SF3B1 is detected as a mutational cancer driver in 2 cancer types: Breast carcinoma, Chronic lymphocytic leukemia and in the PAN-cancer analysis

SF3B1
Ensembl id ENSG00000115524
Mutated samples
Coding Sequence 144 (2.1%)
Protein Affecting 121 (1.8%)
Mode of action Activating
Known driver Yes
Cancer type Signals (Biases)
BRCA CFR
CLL CF
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SF3B1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Chronic lymphocytic leukemia Yes 33 32 11.03
Breast carcinoma Yes 23 23 2.00
Cutaneous melanoma Yes 24 18 4.88
Lung adenocarcinoma Yes 6 5 1.28
Bladder carcinoma Yes 4 4 4.08
Lung squamous cell carcinoma Yes 4 4 2.30
Pancreas adenocarcinoma Yes 4 4 1.87
Stomach adenocarcinoma Yes 5 4 2.48
Head and neck squamous cell carcinoma Yes 7 3 0.80
Hepatocarcinoma Yes 4 2 2.22
Multiple myeloma Yes 3 2 2.90
Colorectal adenocarcinoma Yes 2 2 0.87
Glioblastoma multiforme Yes 2 2 0.53
Esophageal carcinoma Yes 2 2 1.37
Uterine corpus endometrioid carcinoma No 7 5 2.17
Renal clear cell carcinoma No 6 4 0.96
Prostate adenocarcinoma No 2 1 0.41
Acute myeloid leukemia No 1 1 0.51
Neuroblastoma No 1 1 0.48
Lower grade glioma No 2 1 0.59
Small cell lung carcinoma No 1 1 1.45
Serous ovarian adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence