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SEL1L3 has not been detected as a mutational cancer driver

SEL1L3
Ensembl id ENSG00000091490
Mutated samples
Coding Sequence 69 (1.0%)
Protein Affecting 48 (0.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SEL1L3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 31 20 5.42
Lung adenocarcinoma No 3 3 0.77
Breast carcinoma No 3 3 0.26
Renal clear cell carcinoma No 3 3 0.72
Stomach adenocarcinoma No 3 3 1.86
Head and neck squamous cell carcinoma No 4 3 0.80
Prostate adenocarcinoma No 2 2 0.82
Bladder carcinoma No 2 2 2.04
Medulloblastoma No 2 2 0.95
Uterine corpus endometrioid carcinoma No 2 2 0.87
Hepatocarcinoma No 5 1 1.11
Lung squamous cell carcinoma No 2 1 0.57
Thyroid carcinoma No 1 1 0.31
Lower grade glioma No 1 1 0.59
Serous ovarian adenocarcinoma No 1 1 0.32
Multiple myeloma No 1 0 0.00
Diffuse B cell lymphoma No 2 0 0.00
Glioblastoma multiforme No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence