Top
SEC24D is detected as a mutational cancer driver in 1 cancer type: Cutaneous melanoma and in the PAN-cancer analysis

SEC24D
Ensembl id ENSG00000150961
Mutated samples
Coding Sequence 56 (0.8%)
Protein Affecting 46 (0.7%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
CM F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SEC24D gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 14 12 3.25
Breast carcinoma Yes 4 4 0.35
Head and neck squamous cell carcinoma Yes 4 3 0.80
Lung squamous cell carcinoma Yes 3 2 1.15
Renal clear cell carcinoma Yes 2 2 0.48
Non small cell lung carcinoma Yes 2 2 6.45
Lung adenocarcinoma No 8 7 1.79
Uterine corpus endometrioid carcinoma No 6 5 2.17
Prostate adenocarcinoma No 1 1 0.41
Bladder carcinoma No 1 1 1.02
Thyroid carcinoma No 2 1 0.31
Neuroblastoma No 1 1 0.48
Lower grade glioma No 2 1 0.59
Stomach adenocarcinoma No 1 1 0.62
Small cell lung carcinoma No 2 1 1.45
Colorectal adenocarcinoma No 1 1 0.44
Glioblastoma multiforme No 1 1 0.26
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence