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SCN7A has not been detected as a mutational cancer driver

SCN7A
Ensembl id ENSG00000136546
Mutated samples
Coding Sequence 174 (2.6%)
Protein Affecting 140 (2.1%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SCN7A gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 63 42 11.38
Lung adenocarcinoma No 15 14 3.58
Breast carcinoma No 14 14 1.22
Head and neck squamous cell carcinoma No 12 12 3.20
Lung squamous cell carcinoma No 13 11 6.32
Uterine corpus endometrioid carcinoma No 8 7 3.04
Glioblastoma multiforme No 8 6 1.58
Esophageal carcinoma No 7 6 4.11
Prostate adenocarcinoma No 7 5 2.06
Stomach adenocarcinoma No 5 5 3.11
Colorectal adenocarcinoma No 4 4 1.75
Renal clear cell carcinoma No 3 3 0.72
Chronic lymphocytic leukemia No 4 2 0.69
Lower grade glioma No 2 2 1.18
Small cell lung carcinoma No 2 2 2.90
Hepatocarcinoma No 1 1 1.11
Bladder carcinoma No 1 1 1.02
Pancreas adenocarcinoma No 1 1 0.47
Multiple myeloma No 1 1 1.45
Serous ovarian adenocarcinoma No 2 1 0.32
Medulloblastoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence