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SCN3A has not been detected as a mutational cancer driver

SCN3A
Ensembl id ENSG00000153253
Mutated samples
Coding Sequence 213 (3.1%)
Protein Affecting 163 (2.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SCN3A gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 70 48 13.01
Lung adenocarcinoma No 25 22 5.63
Head and neck squamous cell carcinoma No 21 19 5.07
Breast carcinoma No 17 14 1.22
Lung squamous cell carcinoma No 14 13 7.47
Stomach adenocarcinoma No 9 8 4.97
Bladder carcinoma No 7 5 5.10
Serous ovarian adenocarcinoma No 6 5 1.58
Glioblastoma multiforme No 6 5 1.32
Renal clear cell carcinoma No 4 4 0.96
Small cell lung carcinoma No 4 4 5.80
Esophageal carcinoma No 5 4 2.74
Hepatocarcinoma No 2 2 2.22
Uterine corpus endometrioid carcinoma No 8 2 0.87
Non small cell lung carcinoma No 3 2 6.45
Colorectal adenocarcinoma No 3 2 0.87
Prostate adenocarcinoma No 2 1 0.41
Acute myeloid leukemia No 1 1 0.51
Thyroid carcinoma No 1 1 0.31
Lower grade glioma No 2 1 0.59
Chronic lymphocytic leukemia No 3 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence