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SCN11A has not been detected as a mutational cancer driver

SCN11A
Ensembl id ENSG00000168356
Mutated samples
Coding Sequence 231 (3.4%)
Protein Affecting 174 (2.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all SCN11A gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 120 86 23.31
Breast carcinoma No 12 11 0.96
Lung adenocarcinoma No 12 10 2.56
Lung squamous cell carcinoma No 10 9 5.17
Stomach adenocarcinoma No 10 9 5.59
Head and neck squamous cell carcinoma No 13 8 2.13
Colorectal adenocarcinoma No 9 7 3.06
Prostate adenocarcinoma No 6 6 2.47
Esophageal carcinoma No 7 6 4.11
Uterine corpus endometrioid carcinoma No 6 5 2.17
Bladder carcinoma No 6 4 4.08
Glioblastoma multiforme No 3 3 0.79
Serous ovarian adenocarcinoma No 3 2 0.63
Hepatocarcinoma No 2 1 1.11
Medulloblastoma No 1 1 0.48
Pancreas adenocarcinoma No 2 1 0.47
Non small cell lung carcinoma No 1 1 3.23
Chronic lymphocytic leukemia No 3 1 0.34
Multiple myeloma No 1 1 1.45
Lower grade glioma No 1 1 0.59
Small cell lung carcinoma No 1 1 1.45
Renal clear cell carcinoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence