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RYR2 has not been detected as a mutational cancer driver

RYR2
Ensembl id ENSG00000198626
Mutated samples
Coding Sequence 756 (11.1%)
Protein Affecting 545 (8.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all RYR2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 131 96 26.02
Lung adenocarcinoma No 116 90 23.02
Lung squamous cell carcinoma No 80 73 41.95
Head and neck squamous cell carcinoma No 55 42 11.20
Breast carcinoma No 61 36 3.14
Glioblastoma multiforme No 45 30 7.92
Stomach adenocarcinoma No 33 26 16.15
Uterine corpus endometrioid carcinoma No 33 25 10.87
Esophageal carcinoma No 22 17 11.64
Bladder carcinoma No 20 16 16.33
Colorectal adenocarcinoma No 18 16 6.99
Serous ovarian adenocarcinoma No 18 15 4.75
Renal clear cell carcinoma No 18 10 2.40
Prostate adenocarcinoma No 16 9 3.70
Multiple myeloma No 9 7 10.14
Small cell lung carcinoma No 8 7 10.14
Chronic lymphocytic leukemia No 28 6 2.07
Lower grade glioma No 6 6 3.55
Pancreas adenocarcinoma No 8 5 2.34
Hepatocarcinoma No 9 4 4.44
Diffuse B cell lymphoma No 5 4 17.39
Medulloblastoma No 4 3 1.43
Thyroid carcinoma No 3 1 0.31
Acute lymphocytic leukemia No 2 1 0.82
Neuroblastoma No 2 0 0.00
Non small cell lung carcinoma No 2 0 0.00
Pylocytic astrocytoma No 4 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence