IntOGen - RSPO2 gene cancer mutations

RSPO2 is detected as a mutational cancer driver

RSPO2 reports

Methods
Mutation distribution

Gene details

RSPO2
Ensembl ID ENSG00000147655 Transcript ID ENST00000276659 Protein ID ENSP00000276659
Cancer types where is driver 1 Cohorts where is driver 1 Mutated samples 2 Mutations 172
Mode of action Activating
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence