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RSPO1 has not been detected as a mutational cancer driver

RSPO1
Ensembl id ENSG00000169218
Mutated samples
Coding Sequence 39 (0.6%)
Protein Affecting 21 (0.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all RSPO1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 19 12 3.25
Lung adenocarcinoma No 4 2 0.51
Colorectal adenocarcinoma No 2 2 0.87
Prostate adenocarcinoma No 1 1 0.41
Lung squamous cell carcinoma No 1 1 0.57
Renal clear cell carcinoma No 1 1 0.24
Uterine corpus endometrioid carcinoma No 2 1 0.43
Esophageal carcinoma No 1 1 0.68
Breast carcinoma No 2 0 0.00
Thyroid carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Glioblastoma multiforme No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence