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RPE65 has not been detected as a mutational cancer driver

RPE65
Ensembl id ENSG00000116745
Mutated samples
Coding Sequence 54 (0.8%)
Protein Affecting 43 (0.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all RPE65 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 19 14 3.79
Lung adenocarcinoma No 9 9 2.30
Lung squamous cell carcinoma No 3 3 1.72
Colorectal adenocarcinoma No 4 3 1.31
Renal clear cell carcinoma No 3 2 0.48
Small cell lung carcinoma No 2 2 2.90
Head and neck squamous cell carcinoma No 2 2 0.53
Glioblastoma multiforme No 2 2 0.53
Prostate adenocarcinoma No 1 1 0.41
Breast carcinoma No 1 1 0.09
Non small cell lung carcinoma No 2 1 3.23
Chronic lymphocytic leukemia No 3 1 0.34
Serous ovarian adenocarcinoma No 1 1 0.32
Stomach adenocarcinoma No 1 1 0.62
Uterine corpus endometrioid carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence