IntOGen - ROS1 gene cancer mutations

ROS1 is detected as a mutational cancer driver

ROS1 reports

Methods
Mutation distribution

Gene details

ROS1
Ensembl ID ENSG00000047936 Transcript ID ENST00000368508 Protein ID ENSP00000357494
Cancer types where is driver 3 Cohorts where is driver 3 Mutated samples 16 Mutations 1,258
Mode of action Ambiguous
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence