Top
ROBO1 has not been detected as a mutational cancer driver

ROBO1
Ensembl id ENSG00000169855
Mutated samples
Coding Sequence 198 (2.9%)
Protein Affecting 122 (1.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ROBO1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 30 20 5.42
Lung adenocarcinoma No 22 16 4.09
Esophageal carcinoma No 14 10 6.85
Breast carcinoma No 12 9 0.78
Lung squamous cell carcinoma No 9 9 5.17
Stomach adenocarcinoma No 16 9 5.59
Head and neck squamous cell carcinoma No 10 9 2.40
Colorectal adenocarcinoma No 13 8 3.49
Uterine corpus endometrioid carcinoma No 9 7 3.04
Chronic lymphocytic leukemia No 30 5 1.72
Multiple myeloma No 6 5 7.25
Bladder carcinoma No 4 4 4.08
Prostate adenocarcinoma No 4 3 1.23
Glioblastoma multiforme No 5 3 0.79
Serous ovarian adenocarcinoma No 2 2 0.63
Hepatocarcinoma No 4 1 1.11
Renal clear cell carcinoma No 1 1 0.24
Neuroblastoma No 1 1 0.48
Pylocytic astrocytoma No 4 0 0.00
Diffuse B cell lymphoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence