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RNF168 has not been detected as a mutational cancer driver

RNF168
Ensembl id ENSG00000163961
Mutated samples
Coding Sequence 43 (0.6%)
Protein Affecting 23 (0.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all RNF168 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 11 4 1.08
Lung adenocarcinoma No 5 3 0.77
Lung squamous cell carcinoma No 3 3 1.72
Glioblastoma multiforme No 3 3 0.79
Breast carcinoma No 3 2 0.17
Uterine corpus endometrioid carcinoma No 4 2 0.87
Colorectal adenocarcinoma No 3 2 0.87
Bladder carcinoma No 2 1 1.02
Lower grade glioma No 1 1 0.59
Stomach adenocarcinoma No 1 1 0.62
Head and neck squamous cell carcinoma No 3 1 0.27
Thyroid carcinoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Serous ovarian adenocarcinoma No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence