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RNF123 has not been detected as a mutational cancer driver

RNF123
Ensembl id ENSG00000164068
Mutated samples
Coding Sequence 136 (2.0%)
Protein Affecting 51 (0.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all RNF123 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 41 18 4.88
Breast carcinoma No 12 7 0.61
Lung adenocarcinoma No 11 4 1.02
Stomach adenocarcinoma No 9 4 2.48
Head and neck squamous cell carcinoma No 13 4 1.07
Uterine corpus endometrioid carcinoma No 8 3 1.30
Bladder carcinoma No 7 2 2.04
Lung squamous cell carcinoma No 5 2 1.15
Renal clear cell carcinoma No 4 2 0.48
Neuroblastoma No 2 1 0.48
Chronic lymphocytic leukemia No 2 1 0.34
Serous ovarian adenocarcinoma No 1 1 0.32
Small cell lung carcinoma No 1 1 1.45
Glioblastoma multiforme No 7 1 0.26
Prostate adenocarcinoma No 1 0 0.00
Hepatocarcinoma No 2 0 0.00
Pancreas adenocarcinoma No 1 0 0.00
Thyroid carcinoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Lower grade glioma No 1 0 0.00
Colorectal adenocarcinoma No 2 0 0.00
Esophageal carcinoma No 4 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence