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RHOA is detected as a mutational cancer driver in 1 cancer type: Stomach adenocarcinoma and in the PAN-cancer analysis

RHOA
Ensembl id ENSG00000067560
Mutated samples
Coding Sequence 80 (1.2%)
Protein Affecting 35 (0.5%)
Mode of action Activating
Known driver No
Cancer type Signals (Biases)
STAD F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all RHOA gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Stomach adenocarcinoma Yes 10 7 4.35
Head and neck squamous cell carcinoma Yes 7 6 1.60
Bladder carcinoma Yes 5 4 4.08
Cutaneous melanoma Yes 19 4 1.08
Serous ovarian adenocarcinoma Yes 2 2 0.63
Esophageal carcinoma Yes 4 2 1.37
Diffuse B cell lymphoma No 5 5 21.74
Lung adenocarcinoma No 3 1 0.26
Hepatocarcinoma No 4 1 1.11
Breast carcinoma No 3 1 0.09
Uterine corpus endometrioid carcinoma No 3 1 0.43
Colorectal adenocarcinoma No 3 1 0.44
Prostate adenocarcinoma No 5 0 0.00
Lung squamous cell carcinoma No 1 0 0.00
Renal clear cell carcinoma No 2 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Glioblastoma multiforme No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence