Top
RFC4 is detected as a mutational cancer driver in 1 cancer type: Breast carcinoma

RFC4
Ensembl id ENSG00000163918
Mutated samples
Coding Sequence 74 (1.1%)
Protein Affecting 21 (0.3%)
Mode of action Activating
Known driver No
Cancer type Signals (Biases)
BRCA R
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all RFC4 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast carcinoma Yes 11 5 0.44
Lung squamous cell carcinoma No 6 4 2.30
Head and neck squamous cell carcinoma No 5 3 0.80
Bladder carcinoma No 5 2 2.04
Cutaneous melanoma No 10 2 0.54
Uterine corpus endometrioid carcinoma No 5 2 0.87
Renal clear cell carcinoma No 5 1 0.24
Stomach adenocarcinoma No 4 1 0.62
Esophageal carcinoma No 3 1 0.68
Lung adenocarcinoma No 6 0 0.00
Hepatocarcinoma No 2 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Multiple myeloma No 1 0 0.00
Serous ovarian adenocarcinoma No 1 0 0.00
Colorectal adenocarcinoma No 7 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
Glioblastoma multiforme No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence