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RASGRP3 has not been detected as a mutational cancer driver

RASGRP3
Ensembl id ENSG00000152689
Mutated samples
Coding Sequence 71 (1.0%)
Protein Affecting 47 (0.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all RASGRP3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 25 14 3.79
Lung squamous cell carcinoma No 9 8 4.60
Lung adenocarcinoma No 5 5 1.28
Neuroblastoma No 4 3 1.43
Uterine corpus endometrioid carcinoma No 3 2 0.87
Serous ovarian adenocarcinoma No 2 2 0.63
Stomach adenocarcinoma No 3 2 1.24
Colorectal adenocarcinoma No 3 2 0.87
Esophageal carcinoma No 4 2 1.37
Hepatocarcinoma No 1 1 1.11
Bladder carcinoma No 1 1 1.02
Breast carcinoma No 2 1 0.09
Pancreas adenocarcinoma No 1 1 0.47
Renal clear cell carcinoma No 1 1 0.24
Small cell lung carcinoma No 1 1 1.45
Head and neck squamous cell carcinoma No 3 1 0.27
Prostate adenocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence