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RAPGEF4 has not been detected as a mutational cancer driver

RAPGEF4
Ensembl id ENSG00000091428
Mutated samples
Coding Sequence 71 (1.0%)
Protein Affecting 53 (0.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all RAPGEF4 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 22 19 5.15
Lung adenocarcinoma No 6 6 1.53
Stomach adenocarcinoma No 6 5 3.11
Uterine corpus endometrioid carcinoma No 7 4 1.74
Breast carcinoma No 4 3 0.26
Lung squamous cell carcinoma No 3 3 1.72
Bladder carcinoma No 2 2 2.04
Colorectal adenocarcinoma No 3 2 0.87
Glioblastoma multiforme No 2 2 0.53
Prostate adenocarcinoma No 1 1 0.41
Hepatocarcinoma No 3 1 1.11
Renal clear cell carcinoma No 4 1 0.24
Chronic lymphocytic leukemia No 4 1 0.34
Small cell lung carcinoma No 1 1 1.45
Head and neck squamous cell carcinoma No 1 1 0.27
Esophageal carcinoma No 1 1 0.68
Medulloblastoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence