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PUM2 has not been detected as a mutational cancer driver

PUM2
Ensembl id ENSG00000055917
Mutated samples
Coding Sequence 55 (0.8%)
Protein Affecting 40 (0.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PUM2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 9 6 1.63
Breast carcinoma No 6 5 0.44
Lung squamous cell carcinoma No 4 4 2.30
Renal clear cell carcinoma No 4 4 0.96
Lung adenocarcinoma No 3 3 0.77
Bladder carcinoma No 4 3 3.06
Uterine corpus endometrioid carcinoma No 8 3 1.30
Prostate adenocarcinoma No 3 2 0.82
Multiple myeloma No 2 2 2.90
Stomach adenocarcinoma No 3 2 1.24
Small cell lung carcinoma No 2 2 2.90
Thyroid carcinoma No 1 1 0.31
Serous ovarian adenocarcinoma No 2 1 0.32
Colorectal adenocarcinoma No 1 1 0.44
Glioblastoma multiforme No 1 1 0.26
Hepatocarcinoma No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence