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PTPRU is detected as a mutational cancer driver in 1 cancer type: Stomach adenocarcinoma and in the PAN-cancer analysis

PTPRU
Ensembl id ENSG00000060656
Mutated samples
Coding Sequence 114 (1.7%)
Protein Affecting 93 (1.4%)
Mode of action Activating
Known driver No
Cancer type Signals (Biases)
STAD F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PTPRU gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast carcinoma Yes 11 9 0.78
Stomach adenocarcinoma Yes 9 9 5.59
Colorectal adenocarcinoma Yes 10 9 3.93
Small cell lung carcinoma Yes 4 4 5.80
Bladder carcinoma Yes 2 2 2.04
Esophageal carcinoma Yes 4 2 1.37
Cutaneous melanoma No 30 22 5.96
Lung adenocarcinoma No 9 9 2.30
Lung squamous cell carcinoma No 6 6 3.45
Uterine corpus endometrioid carcinoma No 7 6 2.61
Head and neck squamous cell carcinoma No 6 6 1.60
Renal clear cell carcinoma No 5 4 0.96
Prostate adenocarcinoma No 1 1 0.41
Chronic lymphocytic leukemia No 3 1 0.34
Lower grade glioma No 1 1 0.59
Serous ovarian adenocarcinoma No 1 1 0.32
Glioblastoma multiforme No 3 1 0.26
Pylocytic astrocytoma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence