IntOGen - PTPN3 gene cancer mutations

PTPN3 is detected as a mutational cancer driver

PTPN3 reports

Methods
Mutation distribution

Gene details

PTPN3
Ensembl ID ENSG00000070159 Transcript ID ENST00000374541 Protein ID ENSP00000363667
Cancer types where is driver 1 Cohorts where is driver 1 Mutated samples 3 Mutations 343
Mode of action Loss of function
Known driver False

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence