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PTPN18 has not been detected as a mutational cancer driver

PTPN18
Ensembl id ENSG00000072135
Mutated samples
Coding Sequence 28 (0.4%)
Protein Affecting 19 (0.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PTPN18 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung squamous cell carcinoma No 4 4 2.30
Cutaneous melanoma No 5 4 1.08
Renal clear cell carcinoma No 4 3 0.72
Serous ovarian adenocarcinoma No 3 3 0.95
Stomach adenocarcinoma No 2 2 1.24
Lower grade glioma No 1 1 0.59
Colorectal adenocarcinoma No 2 1 0.44
Glioblastoma multiforme No 1 1 0.26
Prostate adenocarcinoma No 1 0 0.00
Lung adenocarcinoma No 1 0 0.00
Bladder carcinoma No 1 0 0.00
Breast carcinoma No 2 0 0.00
Uterine corpus endometrioid carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence