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PTPN13 has not been detected as a mutational cancer driver

PTPN13
Ensembl id ENSG00000163629
Mutated samples
Coding Sequence 135 (2.0%)
Protein Affecting 97 (1.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PTPN13 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 24 17 4.61
Breast carcinoma No 13 11 0.96
Head and neck squamous cell carcinoma No 11 9 2.40
Lung squamous cell carcinoma No 7 7 4.02
Renal clear cell carcinoma No 8 7 1.68
Uterine corpus endometrioid carcinoma No 10 7 3.04
Stomach adenocarcinoma No 11 7 4.35
Lung adenocarcinoma No 13 6 1.53
Esophageal carcinoma No 5 5 3.42
Serous ovarian adenocarcinoma No 4 4 1.27
Bladder carcinoma No 5 3 3.06
Prostate adenocarcinoma No 2 2 0.82
Neuroblastoma No 2 2 0.95
Colorectal adenocarcinoma No 3 2 0.87
Acute lymphocytic leukemia No 2 2 1.64
Hepatocarcinoma No 1 1 1.11
Pancreas adenocarcinoma No 1 1 0.47
Thyroid carcinoma No 1 1 0.31
Chronic lymphocytic leukemia No 7 1 0.34
Small cell lung carcinoma No 1 1 1.45
Glioblastoma multiforme No 2 1 0.26
Medulloblastoma No 1 0 0.00
Lower grade glioma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence