Top
PTPN11 mutations in 1 Colorectal adenocarcinoma project possibly contribute to the detection of the gene in the PAN-cancer anlaysis:

Colorectal adenocarcinoma
Projects 2
229 Samples
Coding sequence mutations (CSMs)
in driver genes 955
in all genes 29233
Protein affecting mutations (PAMs)
in driver genes 905
in all genes 15873
PTPN11
Ensembl id ENSG00000179295
Mutated samples
Coding Sequence 2 (0.9%)
Protein Affecting 2 (0.9%)
Mode of action Activating
Known driver Yes
Project Signals
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Colorectal adenocarcinoma projects in all PTPN11 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Colorectal adenocarcinoma TCGA Yes 2 2 0.87
The mutations needle plot shows the distribution of the observed PTPN11 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification