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PTGS2 has not been detected as a mutational cancer driver

PTGS2
Ensembl id ENSG00000073756
Mutated samples
Coding Sequence 52 (0.8%)
Protein Affecting 37 (0.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PTGS2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 16 11 2.98
Renal clear cell carcinoma No 5 4 0.96
Head and neck squamous cell carcinoma No 5 4 1.07
Lung adenocarcinoma No 5 3 0.77
Prostate adenocarcinoma No 2 2 0.82
Glioblastoma multiforme No 2 2 0.53
Esophageal carcinoma No 2 2 1.37
Bladder carcinoma No 1 1 1.02
Breast carcinoma No 2 1 0.09
Medulloblastoma No 1 1 0.48
Lung squamous cell carcinoma No 2 1 0.57
Neuroblastoma No 1 1 0.48
Serous ovarian adenocarcinoma No 1 1 0.32
Stomach adenocarcinoma No 2 1 0.62
Small cell lung carcinoma No 1 1 1.45
Colorectal adenocarcinoma No 1 1 0.44
Hepatocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence